TRPA1 and CGRP antagonists counteract vesicant-induced skin injury and inflammation
S Achanta, NR Chintagari, M Brackmann… - Toxicology letters, 2018 - Elsevier
The skin is highly sensitive to the chemical warfare agent in mustard gas, sulfur mustard
(SM) that initiates a delayed injury response characterized by erythema, inflammation and
severe vesication (blistering). Although SM poses a continuing threat, used as recently as in
the Syrian conflict, no mechanism-based antidotes against SM are available. Recent studies
demonstrated that Transient Receptor Potential Ankyrin 1 (TRPA1), a chemosensory cation
channel in sensory nerves innervating the skin, is activated by SM and 2‐chloroethyl ethyl …
(SM) that initiates a delayed injury response characterized by erythema, inflammation and
severe vesication (blistering). Although SM poses a continuing threat, used as recently as in
the Syrian conflict, no mechanism-based antidotes against SM are available. Recent studies
demonstrated that Transient Receptor Potential Ankyrin 1 (TRPA1), a chemosensory cation
channel in sensory nerves innervating the skin, is activated by SM and 2‐chloroethyl ethyl …
